abstract：:To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...

journal_title：British journal of cancer

authors： Jammes H,Peyrat JP,Ban E,Vilain MO,Haour F,Djiane J,Bonneterre J

更新日期：1992-08-01 00:00:00

abstract：:The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in the urine of patie...

journal_title：British journal of cancer

authors： Lemaire L,Malet-Martino MC,de Forni M,Martino R,Lasserre B

更新日期：1992-07-01 00:00:00

abstract：:A registry including information about nearly 1,600 cases of retinoblastoma diagnosed in Britain has been created at the Childhood Cancer Research Group. Cases have been classified as 'old germ cell mutation', 'new germ cell mutation' or 'sporadic non-hereditary'. For a population-based group of 918 cases diagnosed be...

journal_title：British journal of cancer

authors： Draper GJ,Sanders BM,Brownbill PA,Hawkins MM

更新日期：1992-07-01 00:00:00

abstract：:Exploring the fundamental mechanisms behind the low tumour uptake of labelled monoclonal antibodies (MoAbs) during in vivo immunotargeting, experiments were performed to estimate the in vivo value of the association constant (Ka) in an experimental targeting reaction. An artificial tumour model was utilised, based on ...

journal_title：British journal of cancer

authors： Fjeld JG,Benestad HB,Stigbrand T,Nustad K

更新日期：1992-07-01 00:00:00

abstract：:The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...

journal_title：British journal of cancer

authors： Cubeddu LX,Hoffmann IS,Fuenmayor NT,Malave JJ

更新日期：1992-07-01 00:00:00

abstract：:In the early period following radical hepatectomy for hepatoma, recurrences in the remaining liver are frequently found. In regenerating liver, implantation and growth of tumour cells released into the portal system during surgical treatment might be promoted. We examined the relationship between liver regeneration an...

journal_title：British journal of cancer

authors： Mizutani J,Hiraoka T,Yamashita R,Miyauchi Y

更新日期：1992-06-01 00:00:00

abstract：:From 1,211 breast cancers, 15 oestrogen receptor (ER) negative-progesterone receptor (PgR) positive breast cancers by conventional dextran coated charcoal steroid binding assays in cytosol were reassessed using Elisa techniques with monoclonal antireceptors antibodies in the cytosolic and nuclear fractions, and immuno...

journal_title：British journal of cancer

authors： Pichon MF,Milgrom E

更新日期：1992-06-01 00:00:00

abstract：:From 1984 to 1989, 63 patients with diffuse, malignant mesothelioma of the pleura were treated with 4-8 courses of high-dose methotrexate (HDMTX, 3 g total dose) and citrovorum factor rescue. There were 61 male and two female patients of median age 60 years. CT scan was performed before and after treatment and used fo...

journal_title：British journal of cancer

authors： Solheim OP,Saeter G,Finnanger AM,Stenwig AE

更新日期：1992-06-01 00:00:00

abstract：:A sequential, quantitative loss of Peanut agglutinin (PNA) binding with progression of mouse mammary cells from normal to preneoplastic to neoplastic phenotypes was observed. Normal mammary epithelium, preneoplastic mammary lesions designated D2HAN (D2-type hyperplastic alveolar nodules) and a series of nine spontaneo...

journal_title：British journal of cancer

authors： Rak JW,McEachern D,Miller FR

更新日期：1992-05-01 00:00:00

abstract：:The present study was designed in order to evaluate the response rate and the toxicity of continuous infusion of Interleukin 2 (IL2) in patients over 65 with metastatic renal cell carcinoma. Twenty-five patients, median age 69 (range 65-77), without any prior systemic anticancer therapy received a continuous infusion ...

journal_title：British journal of cancer

authors： Négrier S,Mercatello A,Bret M,Thiesse P,Blay JY,Coronel B,Merrouche Y,Oskam R,Franks CR,Clavel M

更新日期：1992-05-01 00:00:00

abstract：:The aim of this study was to ascertain whether assessing the growth fraction of cervical carcinoma of 28 patients, using antibody Ki-67, would be of value in clinical practice. The results showed no relationship between growth fraction and age, clinical stage, lymph node involvement or short term (3-5 years) survival....

journal_title：British journal of cancer

authors： Cole DJ,Brown DC,Crossley E,Alcock CJ,Gatter KC

更新日期：1992-05-01 00:00:00

abstract：:Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more differentiated morphology, with the appearance of an increased proportion of multinuclear myotube-like cells,...

journal_title：British journal of cancer

authors： Nicoletti G,De Giovanni C,Landuzzi L,Simone G,Rocchi P,Nanni P,Lollini PL

更新日期：1992-04-01 00:00:00

abstract：:Steroid receptor was assessed immunohistochemically in 158 samples of normal breast for variation through the menstrual cycle. Patterns and intensity of reaction were used in a semi-quantitative scoring system to examine the influence of cycle phase, cycle type, parity and age. The changes in oestrogen receptor for na...

journal_title：British journal of cancer

authors： Battersby S,Robertson BJ,Anderson TJ,King RJ,McPherson K

更新日期：1992-04-01 00:00:00

abstract：:Serum laminin P1 was studied in patients with small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), respiratory infections, pulmonary fibrosis, and in normal subjects. The level of serum laminin P1 was elevated (greater than 1.27 U ml-1) in 58.9% of SCLC and in 11.5% of NSCLC patients. Median value in SCL...

journal_title：British journal of cancer

authors： Nakano T,Iwahashi N,Maeda J,Hada T,Higashino K

更新日期：1992-04-01 00:00:00

abstract：:We have studied the ability of cyclosporin A (CsA) and a non-immunosuppressive analogue, O-acetyl cyclosporin A (OACsA, B3-243) to inhibit the growth of human lung cancer cells in vitro. Using continuous drug exposure and the MTT colorimetric assay to determine cell growth we found that CsA produced partial growth inh...

journal_title：British journal of cancer

authors： Twentyman PR,Wright KA,Wallace HM

更新日期：1992-03-01 00:00:00

abstract：:The mechanism of down-regulation of c-myc RNA associated with androgen-induced suppression of the transformed phenotype in the human prostate carcinoma cell line LNCaP was investigated. The synthetic androgen mibolerone (7 alpha-17 alpha-Dimethyl-19-nortestosterone) reversibly inhibits the proliferation of LNCaP cells...

journal_title：British journal of cancer

authors： Wolf DA,Kohlhuber F,Schulz P,Fittler F,Eick D

更新日期：1992-03-01 00:00:00

abstract：:5-fluorouracil (5FU) is activated intracellularly to cytotoxic 5-fluoronucleotides (FNuct). These were detected non-invasively in rats bearing the Walker carcinosarcoma by 19F-magnetic resonance spectroscopy (MRS) following an i.v. bolus dose of 5FU (50 mg kg-1). Pre-treatment of the rats (3 to 24 h earlier) by methot...

journal_title：British journal of cancer

authors： McSheehy PM,Prior MJ,Griffiths JR

更新日期：1992-03-01 00:00:00

abstract：:A total of 164 consecutive adults with newly confirmed stage IIIB, IVA or IVB Hodgkin's disease (HD) commenced cyclical combination chemotherapy comprising mustine, vinblastine, prednisolone and procarbazine (MVPP) every 6 weeks (145 patients) or minor variants (19) at St Bartholomew's Hospital between 1968 and 1984. ...

journal_title：British journal of cancer

authors： Oza AM,Ganesan TS,Dorreen M,Johnson PW,Waxman J,Gregory W,Lim J,Wright J,Dadiotis L,Barbounis V

更新日期：1992-03-01 00:00:00

abstract：:Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...

journal_title：British journal of cancer

authors： Laderoute KR,Murphy BJ,Short SM,Grant TD,Knapp AM,Sutherland RM

更新日期：1992-02-01 00:00:00

abstract：:A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign...

journal_title：British journal of cancer

authors： Nilsson O,Johansson C,Glimelius B,Persson B,Nørgaard-Pedersen B,Andrén-Sandberg A,Lindholm L

更新日期：1992-02-01 00:00:00

abstract：:Clinico-cytogenetic correlations were assessed in 88 patients with malignant ovarian tumours. Cytogenetic analysis of the primary tumours yielded normal karyotype (N) in 33 patients and abnormal karyotypes (A) in 55 patients. Within the A group, seven tumours had simple abnormalities (AS), i.e., numerical changes only...

journal_title：British journal of cancer

authors： Pejovic T,Himmelmann A,Heim S,Mandahl N,Flodérus UM,Furgyik S,Elmfors B,Helm G,Willén H,Mitelman F

更新日期：1992-02-01 00:00:00

abstract：:The human gene sequences encoding the translation-associated functions of alpha-subunit of elongation factor 1 (EF-1 alpha) and the ubiquitin carboxyl extension protein (HUBCEP80) have been isolated by differential cDNA screening, and found to have significantly higher levels of expression in fibroadenomas (benign) co...

journal_title：British journal of cancer

authors： Adams SM,Sharp MG,Walker RA,Brammar WJ,Varley JM

更新日期：1992-01-01 00:00:00

abstract：:Both biodegradable emboli and pharmacological agents can enhance regional therapy for hepatic targeting. Using a rat model with similar haemodynamic characteristics to human colorectal liver tumour and a radio-labelled marker of similar molecular weight to Adriamycin, we have combined the two approaches to see if the ...

journal_title：British journal of cancer

authors： Carter R,Cooke TG,Hemingway D,McArdle CS,Angerson W

更新日期：1992-01-01 00:00:00

abstract：:Specimens from 45 patients with previously-untreated non-small cell lung cancer (NSCLC) were tested for in vitro chemosensitivity to ten drugs utilising the DiSC assay, which measures cell kill in the total (largely non-dividing) tumour cell population. Thirty-five assays were successful and 25 patients with advanced ...

journal_title：British journal of cancer

authors： Wilbur DW,Camacho ES,Hilliard DA,Dill PL,Weisenthal LM

更新日期：1992-01-01 00:00:00

abstract：:The tumour suppressor gene p53 has been found to be mutated or inactivated at high frequency in several common human tumours. We have examined a series of exocrine pancreatic carcinomas for over-expression of mutant forms of p53 by immunohistochemistry with a panel of specific antibodies. We found immunodetectable p53...

journal_title：British journal of cancer

authors： Barton CM,Staddon SL,Hughes CM,Hall PA,O'Sullivan C,Klöppel G,Theis B,Russell RC,Neoptolemos J,Williamson RC

更新日期：1991-12-01 00:00:00

abstract：:There is increasing evidence that essential fatty acids (EFA) may have a role to play in the aetiology of some types of cancer although their precise mode of action is unknown. Differences in the metabolism of EFA between patients with benign or malignant prostatic disease may help to elucidate their role in the latte...

journal_title：British journal of cancer

authors： Chaudry A,McClinton S,Moffat LE,Wahle KW

更新日期：1991-12-01 00:00:00

abstract：:Previous studies have demonstrated that BR-931, a hepatic peroxisome proliferator, can induce liver tumours in mice and rats. Since alterations in gene expression may play a critical role in multistage hepatocarcinogenesis, the present studies examined the expression of the c-myc, c-H-ras, epidermal growth factor (EGF...

journal_title：British journal of cancer

authors： Hsieh LL,Shinozuka H,Weinstein IB

更新日期：1991-11-01 00:00:00

abstract：:Collagen breakdown, and thus bone resorption, can now be assessed by measuring the urinary excretion of the collagen crosslinks, pyridinoline (Pyd) and deoxypyridinoline (Dpd). In a pilot study we measured Pyd and Dpd in 20 patients with breast cancer, ten with known bone metastases and ten with no recognised metastas...

journal_title：British journal of cancer

authors： Paterson CR,Robins SP,Horobin JM,Preece PE,Cuschieri A

更新日期：1991-11-01 00:00:00

abstract：:Ninety-two consecutive adult patients admitted with acute life-threatening complications of haematological malignancy were studied to determine long term outcome. The quality of life was evaluated in seven long term survivors who are currently alive more than 1 year after hospital discharge using three validated metho...

journal_title：British journal of cancer

authors： Yau E,Rohatiner AZ,Lister TA,Hinds CJ

更新日期：1991-11-01 00:00:00

abstract：:BW12C (5-[2-formyl-3-hydroxypenoxyl] pentanoic acid) is an agent which stabilises oxyhaemoglobin and thus reduces oxygen delivery to tissues. It is of interest as a possible potentiator of bioreductive agents and/or hyperthermia. The increases in radiobiological hypoxic fraction of RIF-1 and KHT tumours 30 min after 7...

journal_title：British journal of cancer

authors： Honess DJ,Hu DE,Bleehen NM

更新日期：1991-10-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) were obtained from patients receiving radioactive murine monoclonal antibody (MAb) therapy for malignant epithelial tumours, as well as normal controls, and were tested for the ability of T cells to proliferate in vitro in the presence of the MAb administered for therapy (HMF...

journal_title：British journal of cancer

authors： Kosmas C,Epenetos AA,Courtenay-Luck NS

更新日期：1991-09-01 00:00:00

abstract：:Expression of the tumour suppressor gene p53 was examined in squamous cell carcinoma of the head and neck using two p53 antibodies, PAb 421 and PAb 1801. Elevated p53 expression was found in 67% of the 73 patients investigated. P53 expression was not found to correlate with whether the patient had been previously trea...

journal_title：British journal of cancer

authors： Field JK,Spandidos DA,Malliri A,Gosney JR,Yiagnisis M,Stell PM

更新日期：1991-09-01 00:00:00

abstract：:Perforin (PFP) is a cytotoxic protein released from killer cells. PFP immunoreactivity in human peripheral blood lymphocytes (PBL) and tumour infiltrating lymphocytes (TIL) was investigated immunocytochemically with the aid of an anti-PFP monoclonal antibody. PFP was detected in the cytoplasm of 10% of PBL. We perform...

journal_title：British journal of cancer

authors： Nakanishi H,Monden T,Morimoto H,Kobayashi T,Shimano T,Mori T

更新日期：1991-08-01 00:00:00

abstract：:Eighty-nine fresh tissue samples from flat colonic mucosa, polypoid lesions, macroscopically evident carcinomas, and metastatic carcinomas from ten patients with longstanding ulcerative colitis (greater than or equal to 8 years duration) were analysed by DNA flow cytometry and light microscopy. Of a total of ten carci...

journal_title：British journal of cancer

authors： Meling GI,Clausen OP,Bergan A,Schjølberg A,Rognum TO

更新日期：1991-08-01 00:00:00

abstract：:Forty-three children with malignant soft tissue sarcomas (IRS Groups II-IV) were treated with rapid dose delivery chemotherapy protocol comprising six courses of vincristine, adriamycin and cyclophosphamide, given in most cases within 8 weeks (Rapid VAC). This was followed in 36 patients by high dose melphalan with au...

journal_title：British journal of cancer

authors： Pinkerton CR,Groot-Loonen J,Barrett A,Meller ST,Tait D,Ashley S,McElwain TJ

更新日期：1991-08-01 00:00:00

abstract：:In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11 patients in their first relapse of acute leukaemia achieved complete remission. Cross resistance between Ara-C and Aza-dC w...

journal_title：British journal of cancer

authors： Richel DJ,Colly LP,Kluin-Nelemans JC,Willemze R

更新日期：1991-07-01 00:00:00

abstract：:Regional chemotherapy is commonly used to treat patients with colorectal liver metastases. However, improvement in survival has still not been demonstrated. Cytotoxic loaded albumin microspheres for arterial administration have been described as a means of improving the the therapeutic index, but their distribution de...

journal_title：British journal of cancer

authors： Goldberg JA,Thomson JA,Bradnam MS,Fenner J,Bessent RG,McKillop JH,Kerr DJ,McArdle CS

更新日期：1991-07-01 00:00:00

abstract：:Hepatic infiltration by lymphoma can be difficult to detect by conventional methods. We have studied 22 patients in vivo 31P magnetic resonance spectroscopy of the liver and compared the results with the clinical staging and assessment of liver involvement by computed tomography (CT), ultrasound (US), and liver functi...

journal_title：British journal of cancer

authors： Dixon RM,Angus PW,Rajagopalan B,Radda GK

更新日期：1991-06-01 00:00:00

abstract：:A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB). The antibody, 636 (Robins et al., 1990), induced significant RTA...

journal_title：British journal of cancer

authors： Embleton MJ,Charleston A,Robins RA,Pimm MV,Baldwin RW

更新日期：1991-05-01 00:00:00

abstract：:Dormant and regressing implants of C3H mammary carcinoma MC2 were always found to be surrounded by a cellular fibrous capsule where macrophages and T cells predominated as the cellular elements. Macrophages were always closely associated with the collagen deposition, and stained with anti-collagen type I immuno-peroxi...

journal_title：British journal of cancer

authors： Vaage J,Harlos JP

更新日期：1991-05-01 00:00:00